Metoperil AM 50 Tablet is a fixed-dose combination of two well-established antihypertensive agents: Metoprolol Succinate (50 mg) and Amlodipine (5 mg). This dual-action medication is primarily prescribed for the treatment of high blood pressure and to prevent cardiovascular complications such as heart attacks and strokes. It is also used in managing chronic stable angina and other heart-related conditions.
Metoprolol Succinate is a cardioselective beta-1 adrenergic receptor blocker that primarily acts on the heart. It works by slowing down the heart rate and reducing the force of contraction, thereby decreasing the oxygen demand of the heart. This action is especially beneficial in patients with hypertension and those recovering from myocardial infarction. As an extended-release formulation, it ensures a steady therapeutic effect throughout the day with once-daily dosing.
Amlodipine is a dihydropyridine calcium channel blocker that functions by relaxing the smooth muscles of blood vessels. This vasodilatory action reduces peripheral vascular resistance, thereby lowering blood pressure and improving blood flow. It also provides effective control of chest pain (angina) by increasing the oxygen supply to the heart muscle.
The combination of Metoprolol Succinate and Amlodipine in a single tablet provides a synergistic approach to blood pressure control. While Metoprolol reduces the cardiac workload, Amlodipine manages vascular resistance, making this formulation ideal for patients requiring multi-mechanism therapy. Additionally, using a fixed-dose combination improves patient adherence and simplifies treatment regimens.
Metoperil AM 50 Tablet falls under the Hypertension/Blood Pressure and Cardiovascular therapeutic segments and is also categorized under General medicines, as it is commonly prescribed in primary healthcare for long-term cardiovascular management.