Ramipil 5 tablet is a long-acting angiotensin-converting enzyme (ACE) inhibitor used primarily to treat high blood pressure and heart failure. It works by inhibiting the enzyme responsible for converting angiotensin I into angiotensin II, a potent vasoconstrictor. This action relaxes blood vessels, lowers vascular resistance, and reduces blood pressure while decreasing the workload on the heart. Ramipril also reduces aldosterone secretion, which helps prevent sodium and fluid retention, offering additional cardiovascular protection. The 5 mg strength is typically prescribed as a maintenance dose for patients with hypertension, post-myocardial infarction, or heart failure who have been stabilized on lower doses. Beyond controlling blood pressure, Ramipril is known to provide cardio- and reno-protective effects, making it beneficial for patients with diabetes or chronic kidney disease to slow the progression of nephropathy.
Common side effects include dizziness, headache, fatigue, and a persistent dry cough (common with ACE inhibitors). Some patients may experience low blood pressure, nausea, or gastrointestinal discomfort. Rare but serious adverse effects include hyperkalemia, angioedema (swelling of the face, lips, or throat), and kidney function impairment. Any signs of facial swelling or difficulty breathing require immediate medical attention.
Ramipril 5 mg Tablet is indicated for the management of essential hypertension, congestive heart failure, and to reduce the risk of cardiovascular death, stroke, and myocardial infarction in high-risk patients. It is also used to slow the progression of kidney disease in patients with diabetic or non-diabetic nephropathy.
Ramipril 5 mg should be taken only under the guidance of a healthcare professional. It is contraindicated in pregnancy, especially during the second and third trimesters, due to the risk of fetal toxicity. Caution should be used in patients with bilateral renal artery stenosis, severe kidney impairment, or a history of angioedema. Potassium supplements and potassium-sparing diuretics should be avoided unless prescribed, as ACE inhibitors can increase serum potassium levels. Alcohol intake should be minimized as it may enhance the blood pressure-lowering effect. Abrupt discontinuation should be avoided to prevent a rebound rise in blood pressure. Regular monitoring of blood pressure, kidney function, and electrolytes is recommended for safe and effective long-term therapy.
Store Ramipril 5 mg Tablet in a cool, dry place below 30°C, away from moisture and direct sunlight. Keep the medication in its original packaging and out of reach of children. Do not use beyond the expiry date mentioned on the strip.